Canine CTR&RAMP1 COS7
CBP71647
詢 價
索取protocol
產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫
| I. Background | |
| 犬 CTR（Calcitonin Receptor，基因 CALCR）? 是 Class B G 蛋白偶聯(lián)受體，結(jié)合降鈣素（Calcitonin）激活 Gs→cAMP 通路，主要分布于破骨細胞和腎，調(diào)控鈣磷穩(wěn)態(tài)及骨吸收；犬 RAMP1（Receptor Activity Modifying Protein 1，基因 RAMP1）? 是單次跨膜輔助蛋白，與 CTR 或 CLR（CALCRL）異源二聚化，決定配體特異性——CTR+RAMP1 形成淀粉樣多肽（Amylin/IAPP）受體，CLR+RAMP1 形成 CGRP 受體，參與血管舒張與疼痛調(diào)節(jié)。 | |
| II. Description | |
| Canine CTR&RAMP1 COS7 細胞藥靶模型很好的模擬了體內(nèi) CTR&RAMP1 的信號轉(zhuǎn)導(dǎo)過程。 | |
| III. Introduction | |
| Host Cell: |
COS7 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: |
DMEM+10%FBS+2μg/ml Puromycin+5μg/ml Blasticidin
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| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): |
Functional assay for Canine CTR&RAMP1 |
| Transducer: | Gs |
| IV. Representative Data | |
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