hSORT1/MC-38
CBPG0276
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| I. Background | |
| SORT1基因編碼Sortilin蛋白，是VPS10相關(guān)Sortilin家族的重要成員，在細(xì)胞內(nèi)主要扮演“分揀受體”的角色。它的核心功能是將特定蛋白質(zhì)從高爾基體精確轉(zhuǎn)運(yùn)至溶酶體、內(nèi)體或細(xì)胞表面，同時(shí)還能與proBDNF等關(guān)鍵分子結(jié)合，介導(dǎo)神經(jīng)元凋亡等信號傳導(dǎo)過程。在臨床層面，SORT1基因的表達(dá)水平與血液中低密度脂蛋白膽固醇（LDL-C）濃度及心肌梗死患病風(fēng)險(xiǎn)顯著相關(guān)，是脂質(zhì)代謝和心血管疾病研究中的重要關(guān)注點(diǎn)。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hSORT1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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