Rat CXCR2 CHO
CBP71651
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| I. Background | |
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大鼠CXCR2(C-X-C趨化因子受體2型)是由Cxcr2基因(也曾被稱為Il8rb)編碼的G蛋白偶聯(lián)受體。它在氨基酸序列全長359個殘基,主要表達(dá)于中性粒細(xì)胞等免疫細(xì)胞表面。 在功能上,它的核心作用是介導(dǎo)中性粒細(xì)胞的趨化與活化,是啟動炎癥反應(yīng)的關(guān)鍵分子。其參與的信號通路(如PI3K/Akt、MAPK/ERK等)在細(xì)胞遷移、增殖、血管生成及組織修復(fù)中發(fā)揮多重調(diào)節(jié)作用。因此,該受體是研究炎癥、神經(jīng)病理性疼痛及腫瘤等疾病的重要靶點(diǎn)。 |
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| II. Description | |
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Rat CXCR2 CHO 細(xì)胞,在 CHO 細(xì)胞的基礎(chǔ)上,穩(wěn)定表達(dá)Rat CXCR2。 |
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| III. Introduction | |
| Expressed gene: | Rat CXCR2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K + 10%FBS + 5μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional assay for Rat CXCR2 |
| Transducer: | Gi |
IV. Representative Data![]() Figure 1. HTRF cAMP Assay with Rat CXCR2 CHO(C17). |
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