TSLPR CHO
CBP74589
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產(chǎn)品描述
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| I. Background | |
| TSLPR(胸腺基質(zhì)淋巴細胞生成素受體)是由CRLF2基因編碼的I型細胞因子受體。它的核心功能是與IL-7受體α鏈(IL-7Rα)形成異源二聚體復(fù)合物,共同構(gòu)成TSLP的功能性高親和力受體。 該受體主要表達于免疫和造血細胞,在TSLP刺激下激活STAT3、STAT5和JAK2等信號通路,調(diào)控細胞增殖、造血系統(tǒng)發(fā)育以及Th2型免疫應(yīng)答等過程。 在臨床意義上,CRLF2基因的重排與B系急性淋巴細胞白血?。˙-ALL)的發(fā)生密切相關(guān),使其成為一個重要的預(yù)后標(biāo)志物和治療靶點。 | |
| II. Description | |
| TSLPR CHO細胞,在 CHO-K1細胞的基礎(chǔ)上,穩(wěn)定表達 TSLPR 。 | |
| III. Introduction | |
| Expressed gene: | TSLPR |
| Host Cell: | CHO |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
![]() Figure 1. Recombinant TSLPR CHO constitutively expressing TSLPR. |
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