IL10RB CHO
CBP74593
詢 價(jià)
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產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
| I. Background | |
| IL10RB(白細(xì)胞介素-10受體β亞基),也叫做IL-10R2或CRF2-4,是由IL10RB基因編碼的II型細(xì)胞因子受體。 它是IL-10、IL-22、IL-26、IL-28和IFN-λ(IL-29)等多種細(xì)胞因子受體復(fù)合物的共用信號(hào)傳導(dǎo)亞基。它自身不能直接結(jié)合配體,但必須與這些細(xì)胞因子各自的特異性受體α鏈(如IL-10R1)結(jié)合形成復(fù)合物后,才能啟動(dòng)下游的JAK-STAT信號(hào)通路。 在免疫系統(tǒng)中,IL10RB廣泛參與抗炎反應(yīng)、抗病毒免疫和組織屏障保護(hù)等過(guò)程。其編碼基因缺陷與極早發(fā)型炎癥性腸病等疾病相關(guān)。 | |
| II. Description | |
| IL10RB CHO細(xì)胞,在 CHO-K1細(xì)胞的基礎(chǔ)上,穩(wěn)定表達(dá) IL10RB 。 | |
| III. Introduction | |
| Expressed gene: | IL10RB |
| Host Cell: | CHO |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
![]() Figure 1. Recombinant IL10RB CHO constitutively expressing IL10RB. |
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