BAFF CHO
CBP74286
| I. Background | |
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BAFF（B 細胞激活因子，B Cell Activating Factor），也稱為 TNFSF13B（Tumor Necrosis Factor Superfamily Member 13B）或 BLyS（B Lymphocyte Stimulator），是一種屬 于腫瘤壞死因子（TNF）超家族的細胞因子。BAFF 主要由單核細胞、巨噬細胞、樹突狀 細胞和某些基質細胞產生，在 B 細胞的存活、增殖和成熟中起關鍵作用。 |
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| II. Description | |
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BAFF CHO 細胞，在 CHO-K1 細胞的基礎上，穩(wěn)定表達人 BAFF。BAFF CHO 細胞作為 TACI Effector Reporter Cell 細胞或者 BAFFR Effector Reporter Cell 細胞的靶細胞，很好的模擬了體內 TACI&BAFF 或者 BAFFR&BAFF 的信號轉導過程，原理見下圖所示。
Figure 2. BAFFR&BAFF 信號轉導模型原理圖
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| III. Introduction | |
| Expressed gene: | BAFF |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+600 μg/ml Hygromycin B |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
IV. Representative Data Figure 3. Recombinant BAFF CHO stably expressing BAFF.  Figure 4. Blocking of BAFF induced TACI Effector Reporter Cell(C32) Activity by BAFF Neutralization Ab with BAFF CHO. |
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 Figure 5. Blocking of BAFF induced BAFFR Effector Reporter Cell(C14) Activity by BAFFR Blocking Ab with BAFF CHO. Blocking of BAFF induced BAFFR Effector Reporter Cell(C14) Activity by BAFFR Blocking Ab with BAFF CHO. |
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