Mouse CTR&RAMP1 UM-UC-3
CBP71649
詢(xún) 價(jià)
索取protocol
產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
| I. Background | |
| 小鼠 Calcr（Calcitonin Receptor, CTR）? 是 B 類(lèi) GPCR，單獨(dú)高親和結(jié)合降鈣素（Calcitonin）激活 Gs/cAMP 通路，抑制破骨細(xì)胞骨吸收；Ramp1（Receptor Activity-Modifying Protein 1）? 為單次跨膜輔助蛋白，與 Calcr 異源二聚化形成 AMY1（Amylin Receptor 1），使復(fù)合物對(duì)胰淀素（Amylin/IAPP）親和力升高、降鈣素親和力降低，主要在下丘腦、孤束核及骨組織表達(dá)，參與攝食抑制、血糖調(diào)節(jié)和骨代謝。 | |
| II. Description | |
| Mouse CTR&RAMP1 UM-UC-3 細(xì)胞藥靶模型很好的模擬了體內(nèi) CTR&RAMP1 的信號(hào)轉(zhuǎn)導(dǎo)過(guò)程。 | |
| III. Introduction | |
| Host Cell: |
UM-UC-3 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: |
MEM+10%FBS+1% NEAA+ 1mM NaP+2μg/ml Puromycin+5μg/ml Blasticidin
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| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): |
Functional assay for Mouse CTR&RAMP1 |
| Transducer: | Gs |
| IV. Representative Data | |
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